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Which symptom is characteristic of peptic ulcer disease (PUD)?

Symptom relief after taking nonsteroidal anti-inflammatory drugs

Sharp pain that is typically located in both lower abdominal quadrants

Passage of bright red blood in the stool or coughing up blood

Burning or gnawing stomach pain that subsides immediately after eating

Peptic ulcer disease typically causes a burning or gnawing pain in the upper abdomen (epigastric region) that is relieved by eating. This relief after meals is a classic pattern, especially for duodenal ulcers, because food buffers stomach acid and temporarily reduces irritation. The other descriptions don’t fit as well: lower-abdominal sharp pain isn’t the usual location for ulcers; passing bright red blood in stool or coughing up blood points to GI bleeding but not the common pain pattern of PUD; and while NSAIDs can contribute to ulcers, relief after taking NSAIDs would contradict the disease’s usual trigger and presentation. So the burning, gnawing epigastric pain that improves after eating best matches peptic ulcer disease.

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